Protein Details: Aquaporin-3

Protein ID

ICDB_Pro_1295

Protein Name

Aquaporin-3

Gene Name

Aqp3

Organism

Mus musculus (Mouse)

Length

292 amino acids

AlphaFoldDB

AF-Q8R2N1-F1-model_v4.pdb

Function

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration;wound healing;and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water;thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.

Sequence

MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYALAQTLGAFLGAGIVFGLYYDAIWAFANNELFVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGRHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSTEEENVKLAHMKHKEQI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Diarrhea

Location

Detected in principal cells in collecting ducts in kidney medulla (at protein level) (PubMed:16641094). Renal medulla and colon. Predominantly in the inner medulla. Predominantly in the inner medulla. Predominantly in the inner medulla. Expressed in basal layer of epidermal keratinocytes

DOI ID

10.1073/pnas.1230416100; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1074/jbc.m001119200; 10.1073/pnas.0602087103; 10.1095/biolreprod.106.059261; 10.1016/j.cell.2010.12.001

RefSeq

NP_057898.2